diff --git a/Cargo.lock b/Cargo.lock
index d68330cfb15c2..fdc9f2807e79c 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -7070,9 +7070,9 @@ checksum = "dbf0c48bc1d91375ae5c3cd81e3722dff1abcf81a30960240640d223f59fe0e5"
 
 [[package]]
 name = "proc-macro2"
-version = "1.0.39"
+version = "1.0.49"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c54b25569025b7fc9651de43004ae593a75ad88543b17178aa5e1b9c4f15f56f"
+checksum = "57a8eca9f9c4ffde41714334dee777596264c7825420f521abc92b5b5deb63a5"
 dependencies = [
  "unicode-ident",
 ]
diff --git a/client/chain-spec/derive/Cargo.toml b/client/chain-spec/derive/Cargo.toml
index d733bda9b1692..32fe238093df0 100644
--- a/client/chain-spec/derive/Cargo.toml
+++ b/client/chain-spec/derive/Cargo.toml
@@ -16,6 +16,6 @@ proc-macro = true
 
 [dependencies]
 proc-macro-crate = "1.1.3"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.10"
 syn = "1.0.98"
diff --git a/client/tracing/proc-macro/Cargo.toml b/client/tracing/proc-macro/Cargo.toml
index 031f1fe49d970..c3d07bbfc8c15 100644
--- a/client/tracing/proc-macro/Cargo.toml
+++ b/client/tracing/proc-macro/Cargo.toml
@@ -16,6 +16,6 @@ proc-macro = true
 
 [dependencies]
 proc-macro-crate = "1.1.3"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = { version = "1.0.10", features = ["proc-macro"] }
 syn = { version = "1.0.98", features = ["proc-macro", "full", "extra-traits", "parsing"] }
diff --git a/frame/election-provider-support/solution-type/Cargo.toml b/frame/election-provider-support/solution-type/Cargo.toml
index a7ce4fa662131..b1becf5b30c79 100644
--- a/frame/election-provider-support/solution-type/Cargo.toml
+++ b/frame/election-provider-support/solution-type/Cargo.toml
@@ -17,7 +17,7 @@ proc-macro = true
 [dependencies]
 syn = { version = "1.0.98", features = ["full", "visit"] }
 quote = "1.0"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 proc-macro-crate = "1.1.3"
 
 [dev-dependencies]
diff --git a/frame/staking/reward-curve/Cargo.toml b/frame/staking/reward-curve/Cargo.toml
index 9e561fea4575b..7b6c83b19d46b 100644
--- a/frame/staking/reward-curve/Cargo.toml
+++ b/frame/staking/reward-curve/Cargo.toml
@@ -16,7 +16,7 @@ proc-macro = true
 
 [dependencies]
 proc-macro-crate = "1.1.3"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.10"
 syn = { version = "1.0.98", features = ["full", "visit"] }
 
diff --git a/frame/support/procedural/Cargo.toml b/frame/support/procedural/Cargo.toml
index 7ddec39cad9fb..e5938c3771c7f 100644
--- a/frame/support/procedural/Cargo.toml
+++ b/frame/support/procedural/Cargo.toml
@@ -16,7 +16,7 @@ proc-macro = true
 
 [dependencies]
 Inflector = "0.11.4"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.10"
 syn = { version = "1.0.98", features = ["full"] }
 frame-support-procedural-tools = { version = "4.0.0-dev", path = "./tools" }
diff --git a/frame/support/procedural/tools/Cargo.toml b/frame/support/procedural/tools/Cargo.toml
index 755483f7db9aa..c78fc84721061 100644
--- a/frame/support/procedural/tools/Cargo.toml
+++ b/frame/support/procedural/tools/Cargo.toml
@@ -13,7 +13,7 @@ targets = ["x86_64-unknown-linux-gnu"]
 
 [dependencies]
 proc-macro-crate = "1.1.3"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.10"
 syn = { version = "1.0.98", features = ["full", "visit", "extra-traits"] }
 frame-support-procedural-tools-derive = { version = "3.0.0", path = "./derive" }
diff --git a/frame/support/procedural/tools/derive/Cargo.toml b/frame/support/procedural/tools/derive/Cargo.toml
index a688ee13a7d17..5afb1b6b2ce07 100644
--- a/frame/support/procedural/tools/derive/Cargo.toml
+++ b/frame/support/procedural/tools/derive/Cargo.toml
@@ -15,6 +15,6 @@ targets = ["x86_64-unknown-linux-gnu"]
 proc-macro = true
 
 [dependencies]
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = { version = "1.0.10", features = ["proc-macro"] }
 syn = { version = "1.0.98", features = ["proc-macro", "full", "extra-traits", "parsing"] }
diff --git a/primitives/api/proc-macro/Cargo.toml b/primitives/api/proc-macro/Cargo.toml
index 0a57be8d7a300..d9358f0d2aef5 100644
--- a/primitives/api/proc-macro/Cargo.toml
+++ b/primitives/api/proc-macro/Cargo.toml
@@ -18,7 +18,7 @@ proc-macro = true
 [dependencies]
 quote = "1.0.10"
 syn = { version = "1.0.98", features = ["full", "fold", "extra-traits", "visit"] }
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 blake2 = { version = "0.10.2", default-features = false }
 proc-macro-crate = "1.1.3"
 
diff --git a/primitives/core/hashing/proc-macro/Cargo.toml b/primitives/core/hashing/proc-macro/Cargo.toml
index 8f4f4e0c873ef..22d8e40b4c03f 100644
--- a/primitives/core/hashing/proc-macro/Cargo.toml
+++ b/primitives/core/hashing/proc-macro/Cargo.toml
@@ -16,7 +16,7 @@ targets = ["x86_64-unknown-linux-gnu"]
 proc-macro = true
 
 [dependencies]
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.6"
 syn = { version = "1.0.98", features = ["full", "parsing"] }
 sp-core-hashing = { version = "4.0.0", default-features = false, path = "../" }
diff --git a/primitives/runtime-interface/proc-macro/Cargo.toml b/primitives/runtime-interface/proc-macro/Cargo.toml
index 6f6b71dc24658..147cca3013d4d 100644
--- a/primitives/runtime-interface/proc-macro/Cargo.toml
+++ b/primitives/runtime-interface/proc-macro/Cargo.toml
@@ -18,6 +18,6 @@ proc-macro = true
 [dependencies]
 Inflector = "0.11.4"
 proc-macro-crate = "1.1.3"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.10"
 syn = { version = "1.0.98", features = ["full", "visit", "fold", "extra-traits"] }
diff --git a/primitives/version/proc-macro/Cargo.toml b/primitives/version/proc-macro/Cargo.toml
index 3d129d4753a15..cf0efdf11b517 100644
--- a/primitives/version/proc-macro/Cargo.toml
+++ b/primitives/version/proc-macro/Cargo.toml
@@ -17,7 +17,7 @@ proc-macro = true
 
 [dependencies]
 codec = { package = "parity-scale-codec", version = "3.0.0", features = [ "derive" ] }
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.10"
 syn = { version = "1.0.98", features = ["full", "fold", "extra-traits", "visit"] }
 
diff --git a/test-utils/derive/Cargo.toml b/test-utils/derive/Cargo.toml
index 4494b55220ef2..6720b56727e8b 100644
--- a/test-utils/derive/Cargo.toml
+++ b/test-utils/derive/Cargo.toml
@@ -10,7 +10,7 @@ description = "Substrate test utilities macros"
 
 [dependencies]
 proc-macro-crate = "1.1.3"
-proc-macro2 = "1.0.37"
+proc-macro2 = "1.0.49"
 quote = "1.0.10"
 syn = { version = "1.0.98", features = ["full"] }