diff --git a/pyproject.toml b/pyproject.toml
index f79b16ac5a2..1a444938617 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,3 +1,59 @@
+[build-system]
+requires = ["setuptools>=68.0", "wheel"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "PyLabRobot"
+description = "A hardware agnostic platform for lab automation"
+readme = "README.md"
+requires-python = ">=3.9"
+license = {text = "MIT"}
+dynamic = ["version"]
+dependencies = ["typing_extensions==4.15.0"]
+
+[project.optional-dependencies]
+fw = ["pyserial==3.5", "pyusb==1.3.1", "libusb-package==1.0.26.1"]
+http = ["requests==2.32.5", "types-requests==2.32.4.20250913"]
+plate_reading = ["pylibftdi==0.23.0"]
+websockets = ["websockets==15.0.1"]
+visualizer = ["websockets==15.0.1"]
+opentrons = ["opentrons-http-api-client"]
+server = ["flask[async]==3.1.2"]
+inheco = ["hid==1.0.8"]
+agrow = ["pymodbus==3.6.8"]
+dev = [
+  "PyLabRobot[fw,http,plate_reading,websockets,visualizer,opentrons,server,inheco,agrow]",
+  "pytest==8.4.2",
+  "pytest-timeout==2.4.0",
+  "mypy==1.18.2",
+  "responses==0.25.8",
+  "sphinx-reredirects==0.1.6",
+  "ruff==0.2.1",
+  "nbconvert==7.16.6",
+  "sphinx-sitemap==2.8.0",
+  "pydata-sphinx-theme==0.16.1",
+  "myst_nb==1.3.0",
+  "sphinx_copybutton==0.5.2",
+]
+all = ["PyLabRobot[dev]"]
+
+[project.scripts]
+lh-server = "pylabrobot.server.liquid_handling_server:main"
+plr-gui = "pylabrobot.gui.gui:main"
+
+[project.urls]
+Homepage = "https://github.com/pylabrobot/pylabrobot"
+
+[tool.setuptools.dynamic]
+version = {file = "pylabrobot/version.txt"}
+
+[tool.setuptools.packages.find]
+namespaces = false
+exclude = ["tools*", "docs*"]
+
+[tool.setuptools.package-data]
+pylabrobot = ["visualizer/*", "version.txt"]
+
 [tool.ruff]
 line-length = 100
 indent-width = 2
@@ -5,3 +61,52 @@ indent-width = 2
 [tool.ruff.lint.per-file-ignores]
 "__init__.py" = ["F401", "F403"]
 
+[tool.pixi.workspace]
+channels = ["conda-forge"]
+platforms = ["linux-64", "osx-arm64", "osx-64", "win-64"]
+
+[tool.pixi.dependencies]
+python = ">=3.9"
+
+[tool.pixi.pypi-dependencies]
+pylabrobot = { path = ".", editable = true }
+
+[tool.pixi.feature.fw.dependencies]
+libusb = "*"
+
+[tool.pixi.feature.fw.pypi-dependencies]
+pylabrobot = { path = ".", editable = true, extras = ["fw"] }
+
+[tool.pixi.feature.plate-reading.dependencies]
+libftdi = "*"
+
+[tool.pixi.feature.plate-reading.pypi-dependencies]
+pylabrobot = { path = ".", editable = true, extras = ["plate_reading"] }
+
+[tool.pixi.feature.inheco.dependencies]
+libhidapi = "*"
+
+[tool.pixi.feature.inheco.pypi-dependencies]
+pylabrobot = { path = ".", editable = true, extras = ["inheco"] }
+
+[tool.pixi.feature.dev.dependencies]
+libusb = "*"
+libftdi = "*"
+libhidapi = "*"
+
+[tool.pixi.feature.dev.pypi-dependencies]
+pylabrobot = { path = ".", editable = true, extras = ["dev"] }
+
+[tool.pixi.tasks]
+test = "python -m pytest -s -v"
+lint = "python -m ruff check pylabrobot"
+format = { cmd = "python -m ruff format pylabrobot && python -m ruff check --fix pylabrobot --select I" }
+format-check = { cmd = "python -m ruff format --check pylabrobot && python -m ruff check pylabrobot --select I" }
+typecheck = "python -m mypy pylabrobot --check-untyped-defs"
+
+[tool.pixi.environments]
+default = { solve-group = "default" }
+fw = { features = ["fw"], solve-group = "fw" }
+plate-reading = { features = ["plate-reading"], solve-group = "plate-reading" }
+inheco = { features = ["inheco"], solve-group = "inheco" }
+dev = { features = ["dev"], solve-group = "dev" }
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 8fcf9c22876..00000000000
--- a/setup.py
+++ /dev/null
@@ -1,90 +0,0 @@
-from setuptools import find_packages, setup
-
-with open("pylabrobot/version.txt", "r", encoding="utf-8") as f:
-  __version__ = f.read().strip()
-
-with open("README.md", "r", encoding="utf-8") as f:
-  long_description = f.read()
-
-
-extras_fw = ["pyserial==3.5", "pyusb==1.3.1", "libusb-package==1.0.26.1"]
-
-extras_http = ["requests==2.32.5", "types-requests==2.32.4.20250913"]
-
-extras_plate_reading = [
-  "pylibftdi==0.23.0",
-]
-
-extras_websockets = ["websockets==15.0.1"]
-
-extras_visualizer = extras_websockets
-
-extras_opentrons = ["opentrons-http-api-client"]
-
-extras_server = [
-  "flask[async]==3.1.2",
-]
-
-
-extras_inheco = ["hid==1.0.8"]
-
-extras_agrow = ["pymodbus==3.6.8"]
-
-extras_dev = (
-  extras_fw
-  + extras_http
-  + extras_plate_reading
-  + extras_websockets
-  + extras_visualizer
-  + extras_opentrons
-  + extras_server
-  + extras_inheco
-  + extras_agrow
-  + [
-    "pydata-sphinx-theme==0.16.1",
-    "myst_nb==1.3.0",
-    "sphinx_copybutton==0.5.2",
-    "pytest==8.4.2",
-    "pytest-timeout==2.4.0",
-    "mypy==1.18.2",
-    "responses==0.25.8",
-    "sphinx-reredirects==0.1.6",
-    "ruff==0.2.1",
-    "nbconvert==7.16.6",
-    "sphinx-sitemap==2.8.0",
-  ]
-)
-
-# Some extras are not available on all platforms. `dev` should be available everywhere
-extras_all = extras_dev
-
-setup(
-  name="PyLabRobot",
-  version=__version__,
-  packages=find_packages(exclude="tools"),
-  description="A hardware agnostic platform for lab automation",
-  long_description=long_description,
-  long_description_content_type="text/markdown",
-  install_requires=["typing_extensions==4.15.0"],
-  url="https://github.com/pylabrobot/pylabrobot.git",
-  package_data={"pylabrobot": ["visualizer/*", "version.txt"]},
-  extras_require={
-    "fw": extras_fw,
-    "http": extras_http,
-    "plate_reading": extras_plate_reading,
-    "websockets": extras_websockets,
-    "visualizer": extras_visualizer,
-    "inheco": extras_inheco,
-    "opentrons": extras_opentrons,
-    "server": extras_server,
-    "agrow": extras_agrow,
-    "dev": extras_dev,
-    "all": extras_all,
-  },
-  entry_points={
-    "console_scripts": [
-      "lh-server=pylabrobot.server.liquid_handling_server:main",
-      "plr-gui=pylabrobot.gui.gui:main",
-    ],
-  },
-)