Question in Nature paper 2015

[kdh4win4]

Dear Dr. Greg Finak
I don't understand why FS scores gap is 40 times. (0.016 vs 0.651)
what is 'degree-six' exactly ?
I understand that PFS is same though.
Thank you for your time.

[kdh4win4]

It is from the COMPASS paper in Nature Biotechnology 2015 online methods first page

[gfinak]

The polyfunctionality score assigns more weight to responses in high degree cell subsets (cell subsets that express more cytokines). That's why the six degree subset gets more weight in the PFS than in the FS.

[kdh4win4]

Dear Greg,
What I don't understand is 40 times gap of FS between single, degree-six, antigen specific subset vs all subsets with degree <4(0,1,2,3).

[gfinak]

Compare the definition of the PolyfunctionalityScore() function against the FunctionalityScore() function to understand how they differ.