diff --git a/.changeset/odd-pigs-hang.md b/.changeset/odd-pigs-hang.md
new file mode 100644
index 0000000000000..b3db5fdbdafaf
--- /dev/null
+++ b/.changeset/odd-pigs-hang.md
@@ -0,0 +1,5 @@
+---
+'@rocket.chat/meteor': patch
+---
+
+Fixes an issue where iframe external commands sent via `window.postMessage` were not being handled correctly when Rocket.Chat was embedded inside an iframe.
diff --git a/apps/meteor/client/startup/index.ts b/apps/meteor/client/startup/index.ts
index 689d5cbe33aa0..ad31ce8030c63 100644
--- a/apps/meteor/client/startup/index.ts
+++ b/apps/meteor/client/startup/index.ts
@@ -3,7 +3,6 @@ import './appRoot';
 import './audit';
 import './callbacks';
 import './deviceManagement';
-import './iframeCommands';
 import './incomingMessages';
 import './roles';
 import './routes';
diff --git a/apps/meteor/client/views/root/AppLayout.tsx b/apps/meteor/client/views/root/AppLayout.tsx
index 33b0714ba3d30..6d44b557a2b31 100644
--- a/apps/meteor/client/views/root/AppLayout.tsx
+++ b/apps/meteor/client/views/root/AppLayout.tsx
@@ -21,6 +21,7 @@ import { useDesktopTitle } from './hooks/useDesktopTitle';
 import { useEmojiOne } from './hooks/useEmojiOne';
 import { useEscapeKeyStroke } from './hooks/useEscapeKeyStroke';
 import { useGoogleTagManager } from './hooks/useGoogleTagManager';
+import { useIframeCommands } from './hooks/useIframeCommands';
 import { useIframeLoginListener } from './hooks/useIframeLoginListener';
 import { useLivechatEnterprise } from './hooks/useLivechatEnterprise';
 import { useLoadMissedMessages } from './hooks/useLoadMissedMessages';
@@ -71,6 +72,7 @@ const AppLayout = () => {
 	useDesktopFavicon();
 	useDesktopTitle();
 	useStartupEvent();
+	useIframeCommands();
 
 	const layout = useSyncExternalStore(appLayout.subscribe, appLayout.getSnapshot);
 
diff --git a/apps/meteor/client/startup/iframeCommands.ts b/apps/meteor/client/views/root/hooks/useIframeCommands.ts
similarity index 60%
rename from apps/meteor/client/startup/iframeCommands.ts
rename to apps/meteor/client/views/root/hooks/useIframeCommands.ts
index 500487b816f0a..88154dca9fc63 100644
--- a/apps/meteor/client/startup/iframeCommands.ts
+++ b/apps/meteor/client/views/root/hooks/useIframeCommands.ts
@@ -1,17 +1,18 @@
 import type { UserStatus, IUser } from '@rocket.chat/core-typings';
 import { escapeRegExp } from '@rocket.chat/string-helpers';
 import { afterLogoutCleanUpCallback } from '@rocket.chat/ui-client';
-import type { LocationPathname } from '@rocket.chat/ui-contexts';
+import { type LocationPathname, useSetting } from '@rocket.chat/ui-contexts';
 import { Meteor } from 'meteor/meteor';
+import { useEffect } from 'react';
 
-import { AccountBox } from '../../app/ui-utils/client/lib/AccountBox';
-import { sdk } from '../../app/utils/client/lib/SDKClient';
-import { capitalize, ltrim, rtrim } from '../../lib/utils/stringUtils';
-import { baseURI } from '../lib/baseURI';
-import { loginServices } from '../lib/loginServices';
-import { settings } from '../lib/settings';
-import { getUser } from '../lib/user';
-import { router } from '../providers/RouterProvider';
+import { AccountBox } from '../../../../app/ui-utils/client/lib/AccountBox';
+import { sdk } from '../../../../app/utils/client/lib/SDKClient';
+import { capitalize, ltrim, rtrim } from '../../../../lib/utils/stringUtils';
+import { baseURI } from '../../../lib/baseURI';
+import { loginServices } from '../../../lib/loginServices';
+import { settings } from '../../../lib/settings';
+import { getUser } from '../../../lib/user';
+import { router } from '../../../providers/RouterProvider';
 
 const commands = {
 	'go'(data: { path: string }) {
@@ -93,27 +94,37 @@ type CommandMessage<TCommandName extends keyof typeof commands = keyof typeof co
 	externalCommand: TCommandName;
 } & Parameters<(typeof commands)[TCommandName]>[0];
 
-window.addEventListener('message', <TCommandMessage extends CommandMessage>(e: MessageEvent<TCommandMessage>) => {
-	if (!settings.peek<boolean>('Iframe_Integration_receive_enable')) {
-		return;
-	}
+export const useIframeCommands = () => {
+	const iframeReceiveEnabled = useSetting('Iframe_Integration_receive_enable');
+	const iframeReceiveOrigin = useSetting('Iframe_Integration_receive_origin', '*');
 
-	if (typeof e.data !== 'object' || typeof e.data.externalCommand !== 'string') {
-		return;
-	}
+	useEffect(() => {
+		if (!iframeReceiveEnabled) {
+			return;
+		}
+		const messageListener = (event: MessageEvent<CommandMessage>) => {
+			if (typeof event.data !== 'object' || typeof event.data.externalCommand !== 'string') {
+				return;
+			}
 
-	const origins = settings.peek<string>('Iframe_Integration_receive_origin') ?? '*';
+			if (iframeReceiveOrigin !== '*' && iframeReceiveOrigin.split(',').indexOf(event.origin) === -1) {
+				console.error('Origin not allowed', event.origin);
+				return;
+			}
 
-	if (origins !== '*' && origins.split(',').indexOf(e.origin) === -1) {
-		console.error('Origin not allowed', e.origin);
-		return;
-	}
+			if (!(event.data.externalCommand in commands)) {
+				console.error('Command not allowed', event.data.externalCommand);
+				return;
+			}
 
-	if (!(e.data.externalCommand in commands)) {
-		console.error('Command not allowed', e.data.externalCommand);
-		return;
-	}
+			const command: (data: MessageEvent['data'], event: MessageEvent) => void = commands[event.data.externalCommand];
+			command(event.data, event);
+		};
+
+		window.addEventListener('message', messageListener);
 
-	const command: (data: any, event: MessageEvent) => void = commands[e.data.externalCommand];
-	command(e.data, e);
-});
+		return () => {
+			window.removeEventListener('message', messageListener);
+		};
+	}, [iframeReceiveEnabled, iframeReceiveOrigin]);
+};