Make the pharmacovigilance analysis results clearer.

[MadDERt]

Construct a clear-result.R script to transform the raw statistical signal detection results into a standardized, publishable format.

Input Validation and Preprocessing

• Integrity Check: Automatically verify the presence of required columns (term column, case count column).
• Data Cleaning: Handle missing values, filter out zero cases, and apply a minimum case count threshold.
• Format Standardization: Automatically convert data.table to data.frame.

Construct a method selection mechanism.

• Custom Selection: Users can define their own combination of methods to use.
• Detailed Report: Display a list of configured methods.

Significance Screening System

• Combined Screening Logic: Retain records if any one method indicates significance.
• Standard Statistical Thresholds (in line with regulatory requirements):
  ROR: ROR > 2 & 95% CI lower limit > 1
  PRR: PRR ≥ 2, χ² ≥ 4, and case count ≥ 3
  BCPNN: IC > 0 & IC025 > 0
  EBGM: EBGM > 2 & EBGM05 > 1
• Custom Criteria Support: Allow users to define their own significance criteria.

Customizable Format Output System

• Users can choose to output in the original format or the processed format.

Data Processing and Display Optimization

• Flexible Sorting: Sort by user-specified columns, supporting both ascending and descending order.
• Row Limitation: Limit the number of output records.
• Value Formatting: Uniformly retain two decimal places.