I wanted something like Org Mode's special edit for the markdown cells. I then found poporg while searching for a solution. It will auto detect the comment prefix to strip off when editing the text and then when you exit it puts the prefix back in with the updated text. This solves another problem for me outside of code-cells, so I prefer this over the triple quote solution for now. Below is how I configured the binding to be the same as org special edit but not conflict with it.
(use-package poporg
:ensure t
:bind
(:map prog-mode-map
("C-c '" . poporg-dwim)
)
(:map poporg-mode-map
("C-c '" . poporg-dwim)
)
)