diff --git a/cdisc_rules_engine/check_operators/dataframe_operators.py b/cdisc_rules_engine/check_operators/dataframe_operators.py
index 0e8eda382..6c42d108d 100644
--- a/cdisc_rules_engine/check_operators/dataframe_operators.py
+++ b/cdisc_rules_engine/check_operators/dataframe_operators.py
@@ -1042,16 +1042,26 @@ def non_empty_within_except_last_row(self, other_value: dict):
     @type_operator(FIELD_DATAFRAME)
     def contains_all(self, other_value: dict):
         target = self.replace_prefix(other_value.get("target"))
+        value_is_literal: bool = other_value.get("value_is_literal", False)
         comparator = other_value.get("comparator")
-        if isinstance(comparator, list):
-            # get column as array of values
-            values = flatten_list(self.value, comparator)
+        if self.is_column_of_iterables(
+            self.value[target]
+        ) and self.is_column_of_iterables(self.value[comparator]):
+            comparison_data = self.get_comparator_data(comparator, value_is_literal)
+            results = []
+            for i in range(len(self.value[target])):
+                target_val = self.value[target].iloc[i]
+                comp_val = comparison_data.iloc[i]
+                results.append(all(is_in(item, comp_val) for item in target_val))
         else:
-            comparator = self.replace_prefix(comparator)
-            values = self.value[comparator].unique()
-        return self.value.convert_to_series(
-            set(values).issubset(set(self.value[target].unique()))
-        )
+            if isinstance(comparator, list):
+                # get column as array of values
+                values = flatten_list(self.value, comparator)
+            else:
+                comparator = self.replace_prefix(comparator)
+                values = self.value[comparator].unique()
+            results = set(values).issubset(set(self.value[target].unique()))
+        return self.value.convert_to_series(results)
 
     @log_operator_execution
     @type_operator(FIELD_DATAFRAME)
diff --git a/cdisc_rules_engine/models/operation_params.py b/cdisc_rules_engine/models/operation_params.py
index 55907a959..1b67e4b60 100644
--- a/cdisc_rules_engine/models/operation_params.py
+++ b/cdisc_rules_engine/models/operation_params.py
@@ -59,3 +59,4 @@ class OperationParams:
     target: str = None
     value_is_reference: bool = False
     namespace: str = None
+    delimiter: str = None
diff --git a/cdisc_rules_engine/operations/operations_factory.py b/cdisc_rules_engine/operations/operations_factory.py
index 2a77adf09..801df7a08 100644
--- a/cdisc_rules_engine/operations/operations_factory.py
+++ b/cdisc_rules_engine/operations/operations_factory.py
@@ -42,6 +42,7 @@
 from cdisc_rules_engine.operations.min_date import MinDate
 from cdisc_rules_engine.operations.minimum import Minimum
 from cdisc_rules_engine.operations.record_count import RecordCount
+from cdisc_rules_engine.operations.split_by import SplitBy
 from cdisc_rules_engine.operations.valid_external_dictionary_code import (
     ValidExternalDictionaryCode,
 )
@@ -121,6 +122,7 @@ class OperationsFactory(FactoryInterface):
         "domain_is_custom": DomainIsCustom,
         "domain_label": DomainLabel,
         "required_variables": RequiredVariables,
+        "split_by": SplitBy,
         "expected_variables": ExpectedVariables,
         "permissible_variables": PermissibleVariables,
         "study_domains": StudyDomains,
diff --git a/cdisc_rules_engine/operations/split_by.py b/cdisc_rules_engine/operations/split_by.py
new file mode 100644
index 000000000..03291daab
--- /dev/null
+++ b/cdisc_rules_engine/operations/split_by.py
@@ -0,0 +1,8 @@
+from cdisc_rules_engine.operations.base_operation import BaseOperation
+
+
+class SplitBy(BaseOperation):
+    def _execute_operation(self):
+        return self.params.dataframe[self.params.target].str.split(
+            self.params.delimiter
+        )
diff --git a/cdisc_rules_engine/utilities/rule_processor.py b/cdisc_rules_engine/utilities/rule_processor.py
index de335af09..05b13d26e 100644
--- a/cdisc_rules_engine/utilities/rule_processor.py
+++ b/cdisc_rules_engine/utilities/rule_processor.py
@@ -423,6 +423,7 @@ def perform_rule_operations(
                 term_pref_term=operation.get("term_pref_term"),
                 namespace=operation.get("namespace"),
                 value_is_reference=operation.get("value_is_reference", False),
+                delimiter=operation.get("delimiter"),
             )
 
             # execute operation