Simulation of tissue-specific knockout/overexpression #242
Description
Hi,
Is there an option to simulate tissue-specific modifications on gene expression? For example, I would be interested in knockouting my gene only in a specific tissue and I would like to simulate this by an in-silico knockout in a corresponding cluster. Similarly, I am interested in a role of given gene in specific cell type. Therefore, it would be useful to simulate over-expression only in a given cluster or in the cells already expressing it.
If I understand it correctly, CellOracle can currently simulate only a complete knockout or over-expression from uniformly active promoter rather than from the native promoter. I believe that cluster-specific modifications of expression level would be highly informative and biologically very relevant.
Best,
Pavel