sjpeg recommends sharp YUV for this image (https://user-images.githubusercontent.com/19407943/33548263-53136816-d8ef-11e7-8994-6a6cfded7912.png):
Riskiness: 60.1 (recommended yuv_mode: SharpYUV420)
But in fact only YUV444 gives transparent results for this image; any chroma subsampling adds very obvious changes to the image.