Skip to content
Merged
Show file tree
Hide file tree
Changes from all commits
Commits
File filter

Filter by extension

Filter by extension

Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
31 changes: 31 additions & 0 deletions doc/amici_refs.bib
Original file line number Diff line number Diff line change
Expand Up @@ -1606,6 +1606,37 @@ @Article{LentBun2025
url = {https://doi.org/10.1371/journal.pcbi.1012733},
}

@Article{SundqvistPod2025,
author = {Nicolas Sundqvist and Henrik Podéus and Sebastian Sten and Maria Engström and Salvador Dura-Bernal and Gunnar Cedersund},
journal = {Computers in Biology and Medicine},
title = {Model-driven meta-analysis establishes a new consensus view: Inhibitory neurons dominate {BOLD-fMRI} responses},
year = {2025},
issn = {0010-4825},
pages = {111014},
volume = {197},
abstract = {Functional magnetic resonance imaging (fMRI) is a pivotal tool for mapping neuronal activity in the brain. Traditionally, the observed hemodynamic changes are assumed to reflect the activity of the most common neuronal type: excitatory neurons. In contrast, recent experiments, using optogenetic techniques, suggest that the fMRI-signal could reflect the activity of inhibitory interneurons. However, these data paint a complex picture, with numerous regulatory interactions, and with responses that sometimes seem to point in different directions. It is therefore not trivial how to quantify the relative contributions of the different cell types into a consensus view compatible with the considered data. To address this, we present a new model-driven meta-analysis, which provides a unified and quantitative explanation for the considered data. This model-driven analysis allows for quantification of the relative contribution of different cell types: the contribution to the BOLD-signal from the excitatory cells is <20 % and 50–80 % comes from the interneurons. Our analysis also provides a mechanistic explanation for the observed experiment-to-experiment differences. For instance, one of the reasons that data seem to point in different directions is a biphasic vascular response, with a transient increase and a subsequent decrease. Our model-based data analysis explains why this biphasic response appears only for high-intensity stimulations and not for low-intensity stimulations. In other words, our meta-analysis goes beyond a simple vote-by-majority and provides a single unified explanation for the considered data. This explanation provides a consensus view that constitutes a paradigm shift in how fMRI can, and cannot, be used to interpret neuronal activity.},
creationdate = {2025-09-23T19:50:09},
doi = {https://doi.org/10.1016/j.compbiomed.2025.111014},
keywords = {fMRI, BOLD, OIS, NVC, Mathematical modelling, Inhibitory neurons},
modificationdate = {2025-09-23T19:50:26},
url = {https://www.sciencedirect.com/science/article/pii/S0010482525013666},
}

@Article{PhilippsSch2025,
author = {Philipps, Maren and Schmid, Nina and Hasenauer, Jan},
journal = {npj Systems Biology and Applications},
title = {Current state and open problems in universal differential equations for systems biology},
year = {2025},
issn = {2056-7189},
month = aug,
number = {1},
volume = {11},
creationdate = {2025-09-23T19:51:56},
doi = {10.1038/s41540-025-00550-w},
modificationdate = {2025-09-23T19:51:56},
publisher = {Springer Science and Business Media LLC},
}

@Comment{jabref-meta: databaseType:bibtex;}

@Comment{jabref-meta: grouping:
Expand Down
18 changes: 17 additions & 1 deletion doc/references.md
Original file line number Diff line number Diff line change
@@ -1,6 +1,6 @@
# References

List of publications using AMICI. Total number is 105.
List of publications using AMICI. Total number is 107.

If you applied AMICI in your work and your publication is missing, please let us know via a new
[GitHub issue](https://github.com/AMICI-dev/AMICI/issues/new?labels=documentation&title=Add+publication&body=AMICI+was+used+in+this+manuscript:+DOI).
Expand Down Expand Up @@ -70,6 +70,13 @@ Cvijovic. 2025. <span>“PEtab.jl: Advancing the Efficiency and Utility of
Dynamic Modelling.”</span> <em>bioRxiv</em>. <a
href="https://doi.org/10.1101/2025.04.30.651378">https://doi.org/10.1101/2025.04.30.651378</a>.
</div>
<div id="ref-PhilippsSch2025" class="csl-entry" role="listitem">
Philipps, Maren, Nina Schmid, and Jan Hasenauer. 2025. <span>“Current
State and Open Problems in Universal Differential Equations for Systems
Biology.”</span> <em>Npj Systems Biology and Applications</em> 11 (1).
<a
href="https://doi.org/10.1038/s41540-025-00550-w">https://doi.org/10.1038/s41540-025-00550-w</a>.
</div>
<div id="ref-SmithMal2025" class="csl-entry" role="listitem">
Smith, Lucian, Rahuman S. Malik-Sheriff, Tung V. N. Nguyen, Henning
Hermjakob, Jonathan Karr, Bilal Shaikh, Logan Drescher, et al. 2025.
Expand All @@ -78,6 +85,15 @@ Hermjakob, Jonathan Karr, Bilal Shaikh, Logan Drescher, et al. 2025.
<em>bioRxiv</em>. <a
href="https://doi.org/10.1101/2025.01.16.633337">https://doi.org/10.1101/2025.01.16.633337</a>.
</div>
<div id="ref-SundqvistPod2025" class="csl-entry" role="listitem">
Sundqvist, Nicolas, Henrik Podéus, Sebastian Sten, Maria Engström,
Salvador Dura-Bernal, and Gunnar Cedersund. 2025. <span>“Model-Driven
Meta-Analysis Establishes a New Consensus View: Inhibitory Neurons
Dominate <span class="nocase">BOLD-fMRI</span> Responses.”</span>
<em>Computers in Biology and Medicine</em> 197: 111014.
https://doi.org/<a
href="https://doi.org/10.1016/j.compbiomed.2025.111014">https://doi.org/10.1016/j.compbiomed.2025.111014</a>.
</div>
</div>
<h1 class="unnumbered" id="section">2024</h1>
<div id="refs" class="references csl-bib-body hanging-indent"
Expand Down
Loading