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V and C region bearing antibody Web Interface
VCAb is a web application to investigate antibody isotypes structural features, bridging antibody sequence repertoire acquired via next generation sequencing to the available antibody structural space of structures covering both V and C region. Antibody structures in VCAb are clearly annotated with isotype, light chain type, structural coverage, information (such as interface residues, CH1-CL torsion angles) related with CH1-CL interface, and in silico mutational scanning profiles.
VCAb is now available online. Users can search for antibodies of their interest, then view and inspect annotations and structures of them interactively.
If you are interested in the generation process of available experimental structural space of antibodies with both V and C regions, please go to Antibody structural space.
As indicated in the navigation bar, four pages are available in VCAb.
In this page, the user can query the database, view the antibody information and inspect the antibody structures interactively. The search page can be divided into 3 panels: the Query Input panel, Antibody Information panel, and Interactive 3D Structure Viewer and Sequence Viewer (Please click on the corresponding link for details).
This page summarizes the statistics of available antibodies in current released version of VCAb. You can view the statistics by different standard: species, isotype, light chain type and structural coverage. Multiple standards can be selected at the same time.
In this page, you can download the annotations for all the antibodies in VCAb. All the sequence in VCAb of both V and C regions are numbered under IMGT scheme, using ANARCI_vc, a package modified from ANARCI to enable both V and C numbering. All the numbered sequence in VCAb can be downloaded here.
This page is a copy of this github wiki.
This page included a brief introduction of VCAb web tool. Way to cite VCAb is also provided here.