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Candace Myers
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canmyers@uw.edu

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Hello, thank you for this awesome resource! I want to bring attention to a possible typo in the "pathogenic (gene)" sequence for ATXN1. The website currently reads "AGC" but I think this is meant to be "GAC" (the reverse of CTG) if I an interpreting this box correctly. Thanks.

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@hdashnow
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Hi Candace,

Thanks for reporting this! I've double-checked, and this motif is correct.
The reverse complement of CTG is CAG.

5' CTG 3'
3' GAC 5' -> 5' CAG 3'

If reading in any frame:
CAG == AGC == GCA

So AGC is a valid motif here.

@hdashnow hdashnow closed this Jan 23, 2026
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3 participants