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Includes all of the analytics done on BRCA data from GHS & UKBB.

The first set of scripts create our case and control groups:

  1. UKBB_BRCA1.Rmd
  2. UKBB_BRCA2.Rmd
  3. GHS_BRCA1.Rmd
  4. GHS_BRCA2.Rmd
  5. avengers.R: Pulls out avengers mutations
  6. avengers_run.R: collect avengers mutations and add to dataframe
  7. exclusion_ids.Rmd: create list of individuals to exclude from control group
  8. dualmutations.Rmd: create list of individuals with >1 mutation in BRCA1 or BRCA2
  9. filter_dataset.R: script to filter genome data for quality

Forest plots:

  1. brca1_forestplots.Rmd
  2. brca2_forestplots.Rmd
  3. forest_plot.R: functions used in above files
  4. forestplots_ukbb.Rmd: forest plots for fellows' symposium poster

Survival plots:

  1. operations.Rmd: mutating operation data for use in censoring for survival plots
  2. survival_analysis_brca1.Rmd
  3. survival_analysis_brca2.Rmd
  4. survival_plot.R: functions used in above files

Other:

  1. case_data.Rmd: link case id #s to actual data
  2. ghs_censoring_script.R: censoring example for Geisinger analysts

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Genetics BRCA1/BRCA2 Analyses

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