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Support for constrained longitudinal data analysis (cLDA) parametrization

enhancementNew feature or requestNew feature or request

Status: Open.

#551 In openpharma/mmrm;

· DavidJesse21 opened on Nov 24, 2025

Comparison to SAS’ PROC MIXED

Status: Open.

#538 In openpharma/mmrm;

· W-APrince opened on Sep 29, 2025

Diagonal covariance structure, un-unique intra subject levels

enhancementNew feature or requestNew feature or request

Status: Open.

#505 In openpharma/mmrm;

· PharmCat opened on May 7, 2025

Spatial gaussian covariance

enhancementNew feature or requestNew feature or request

Status: Open.

#501 In openpharma/mmrm;

· danielinteractive opened on Apr 3, 2025

Calculate (approximate) covariance matrix for covariance estimates themselves

enhancementNew feature or requestNew feature or request

SP13

Status: Open.

#493 In openpharma/mmrm;

· danielinteractive opened on Dec 11, 2024

Add a spatial covariance structure implementing patient level random effects induced covariance

enhancementNew feature or requestNew feature or request

SP8

Status: Open.

#480 In openpharma/mmrm;

· danielinteractive opened on Nov 9, 2024

Add an application vignette

documentationImprovements or additions to documentationImprovements or additions to documentation

good first issueGood for newcomersGood for newcomers

Status: Open.

#448 In openpharma/mmrm;

· danielinteractive opened on Jun 27, 2024

potentially improve warning/error messages

devops

SP3

Status: Open.

#393 In openpharma/mmrm;

· clarkliming opened on Dec 19, 2023

Once default optimizer fails, try all optimizers but with increased number of iterations

enhancementNew feature or requestNew feature or request

SP3

Status: Open.

#385 In openpharma/mmrm;

· danielinteractive opened on Dec 13, 2023

Bootstrapping functionality or interface with bootstrap packages

Status: Open.

#372 In openpharma/mmrm;

· danielinteractive opened on Nov 15, 2023

Add <code>acf</code> (and maybe vignette with some <code>plot</code> examples)

enhancementNew feature or requestNew feature or request

SP5

Status: Open.

#371 In openpharma/mmrm;

· Generalized opened on Nov 13, 2023

Cook's distance or DFFIT, DFBETA, leverage

enhancementNew feature or requestNew feature or request

SP5

Status: Open.

#368 In openpharma/mmrm;

· Generalized opened on Nov 4, 2023